Table 2.
Data representing the basic histological characteristics and quantified immunohistochemistry
| Pain-free group | Painful group | p value | |
|---|---|---|---|
| Mean vessel count | 1.09 (+/− 0.63) | 0.80 (+/− 0.65) | 0.47 |
| Mean nuclei count | 11.6 (+/− 4.1) | 8.0 (+/− 12.5) | 0.57 |
| Median modified Bonar score | 7.0 (6.5–8.0) | 8.0 (6.0–10.0) | 0.59 |
| Proliferation (% PCNA staininga) | 0.04 (0.03–0.06) | 0.04 (0.02–0.12) | 0.86 |
| HIF1alphaa | 0.01 (0.01–0.04) | 0.02 (0.01–0.04) | 0.73 |
| VEGFa | 0.27 (+/− 0.18) | 0.06 (+/− 0.05) | 0.004**b |
| CD45 (% cells positive) | 6.8 (4.7–10) | 12.4 (8.1–16.8) | 0.038* |
| CD206 (% cells positive) | 13.2 (+/− 6.2) | 26.8 (+/− 6.5) | 0.0004**b |
| Lactate dehydrogenasea | 0.001 (0.0004–0.002) | 0.015 (0.01–0.04) | 0.007**b |
| Glutamatea | 0.003 (0.001–0.03) | 0.004 (0.002–0.007) | 0.86 |
| NMDAR1a | 0.013 (0.006–0.015) | 0.025 (0.002–0.037) | 0.61 |
| PGP 9.5 | 0.87 (0.35–1.86) | 3.75 (1.36–4.97) | 0.0079**b |
| mGluR1a | 0.43 (0.24–0.58) | 0.36 (0.24–0.42) | 0.55 |
| mGluR2a | 0.0019 (0.008–0.066) | 0.064 (0.058–0.096) | 0.05* |
| mGluR7a | 0.18 (0.12–0.64) | 0.005 (0.003–0.034) | 0.0019**b |
| KA1 | 0.85 (1.31–2.62) | 4.55 (2.37–7.15) | 0.0028**b |
All data is represented as median (interquartile range) or mean +/− standard deviation unless otherwise stated. Statistical significance is denoted by * p <0.05, ** p <0.01, *** p <0.001 (between groups).
HIF1alpha hypoxia-inducible factor 1-alpha, KA1 kainate receptor 1, mGluR metabotropic glutamate receptor, NMDAR1 N-methyl-D-aspartate receptor, PCNA proliferating cell nuclear antigen, PGP 9.5 protein gene product 9.5, VEGF vascular endothelial growth factor
aDenotes per cell
bDenotes significant result after application of Benjamini-Hochberg procedure