Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(a) Somatic mutations (in red) that are acquired during tumor growth lead to the emergence of new subclones and haplotypes. (b) An illustration of an SNV and read mapping. The figure shows five short reads that are mapped to the indicated SNV location. The reference genotype is A. Among the five reads, two reads have a variant genotype C. So Nst = 5, nst = 2 and the observed VAF is 2=5.
