Fig 6. Antibody targets the worm esophagus and shows distinct response patterns to worm and egg antigens.

Permeabilized whole worms recovered from rhesus macaques, (A) female and (B) male, reacted with FITC-labeled anti-rhesus IgG, showed intrinsic antibodies (green) bound to the tegument, particularly in the head region, but more strikingly along the whole length of the esophageal lumen (arrowed). (C) Time course of antibody response against soluble worm antigen (SWAP), and egg antigen (SEA) preparations. Binding of antibody to both preparations was barely detected during the first 4 weeks. Thereafter the anti-SEA response rose dramatically to reach a high plateau at week 8, but the decline from week 10 onwards was not significant. In contrast, anti-SWAP reactivity rose only slowly from week 4, with its peak appearing as late as week 18. Scale bars: 50 μm (A), 20 μm (B).