Figure 2.

The structure of hDus2 1–340 comprising the catalytic and recognition domains. (a) Domain schematic of hDus2. (b) The structure of hDus2 viewed from the putative tRNA-binding surface. The ribbon diagram is coloured from blue (N-terminus) to red (C-terminus); missing residues 118–128 are indicated by a dashed green ribbon; bound FMN is shown as sticks. (c) Secondary-structure topology diagram [colouring as in (b)] showing domain composition and connectivity. (d) FMN coordination, with FMN and active-site residues shown as sticks, hydrogen bonds shown as dashed lines, atoms coloured according to type and residues forming hydrophobic contacts designated by red semicircles.