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. 2015 Jun 30;71(Pt 7):1564–1571. doi: 10.1107/S1399004715009220

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© Whelan et al. 2015

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

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Comparison of hDus2 with TtDus and analysis of electrostatic surface and sequence conservation. (a) Ribbon diagram showing superposition of hDus2 with TtDus (grey). The boxed area is magnified in (b), showing hDus2 interactions between the catalytic and recognition domains that are not present in bacterial Dus enzymes. (c) hDus2 superposed with the structure of the TtDus–tRNA complex (with TtDus in grey and tRNA in blue). (d) hDus2 molecular surface coloured according to electrostatic potential (±5kT/e; red, negative; blue, positive). (e) hDus2 surface coloured according to sequence conservation: high (purple) to low (yellow).