Fig 5. PINK1-Parkin prevented PA-induced endothelial death.

A. HAECs were transfected with PINK1 or Parkin siRNA followed by treatment with PA for 24 hours. Representative images and quantification of 3 independent TUNEL analysis showed that PINK1 or Parkin siRNA increased PA-induced apoptotic cell death. B. Representative electron microscopy photomicrographs of PA-treated cells show that PINK1 or Parkin siRNA increased apoptotic or necrotic bodies.