Table 1. Mutation spectrum of IDH1/2 genes in cartilaginous tumors.
Gene | Type of mutations | Base change | No. of tumors with mutations (%) |
---|---|---|---|
IDH1 | R132C | CGT>TGT | 16 (44.4) |
IDH1 | R132G | CGT>GGT | 7 (19.4) |
IDH1 | R132F | CGT>CTT | 2 (5.6) |
IDH2 | R172S | AGG>AGC | 4 (11.1) |
IDH2 | R172S | AGG>AGT | 4 (11.1) |
IDH2 | R172T | AGG>ACG | 2 (5.6) |
IDH2 | R172W | AGG>TGG | 1 (2.8) |