Table 1.

Summary characteristics for the Boston Children’s Hospital cohorts. Truncal involvement indicates presence of one or more lipomatous masses on inspection, palpation, or MRI. Limb involvement indicates lipomatous overgrowth by inspection or MRI. Number of participants with limb length discrepancy (LLD), macrodactyly (macro), and syndactyly (syn) is indicated. CM – capillary malformation, LM – lymphatic malformation, VM – venous malformation. Number of participants with LM affecting a specific location (head or neck, trunk, and limb) is indicated, as is number of LMs that by MRI or ultrasonography were microcystic, macrocystic, or a combination.

	LM (n=17)	CLOVES (n=33)	KTS (n=21)	FAVA (n=8)
Sex (M/F)	(11/6)	(18/15)	(13/18)	(3/5)
Truncal involvement	0	26	2	0
Limb involvement (LLD/macro/syn)	4 (0,0,0)	30 (17/22/6)	21 (20/14/4)	8 (0/0/0)
Cutaneous CM and/or LM	0	28	21	0
LM on imaging (head-neck/trunk/limb) [micro/macro/combination]	17 (10/3/4) [1/8/8]	33 (5/13/15) [4/19/10]	21 (0/0/21) [1/11/9]	4
VM on imaging	0	30	20	8
Complications (INF/GIB/DVT/PVT/Wilms/death)	(13/0/0/0/0/0)	(12/7/6/4/1/2)	(13/8/3/0/0/0)	none

Note, LM adjacent to fibro-adipose infiltrated muscle was a frequent histopathologic finding in FAVA. Number of participants with a VM detected by ultrasonography or MRI is indicated. VMs involved the marginal veins or large draining veins in CLOVES and KTS, and were adjacent to the fibro-adipose lesion in FAVA. Complications include infection at site of or originating from a vascular malformation (INF), gastro-intestinal bleed (GIB), deep vein thrombosis ± pulmonary embolism (DVT), portal vein thrombosis (PVT), Wilms tumor (Wilms), and death.