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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Aliment Pharmacol Ther. 2015 Mar 23;41(11):1094–1103. doi: 10.1111/apt.13175

Figure 1.

Figure 1

Conceptual framework for hypothesized mechanisms of rapid clearance of therapeutic anti-TNF biologics in ASUC. (A) High concentrations of circulating and tissue TNF may act as a “sponge” that rapidly “absorbs” or neutralizes standard dose of anti-TNF biologics. (B) Mononuclear cell “sharks” within the upregulated RES may rapidly “chew through” drug-TNF complexes by phagocytosis and proteolyticdegradation. (C) Leaky guts associated with severe colonic inflammation may act as a “sieve”, permitting the excessive fecal loss of therapeutic monoclonal antibody.