. 2015 Jul 3;8:1633–1642. doi: 10.2147/OTT.S87406

Table S1.

Reported cases of mixed acinar-endocrine carcinoma in pancreas

Case	Authors	Sex	Age (years)	Presentation	Location	Size^a (cm)	Metastasis anterior^b	Acinar marker	Endocrine markers	Morphology	Ki-67	Treatment	Postoperative course	Metastasis posterior^c	Year^d
1	Current study	F	65	Jaundice, epigastric pain, diarrhea	Head	8	Liver	Trypsin, chymotrypsin	CGA, SYN, NSE	Predominately solid and partly acinar	10%	PD	12 months without recurrence	N/A	2015
2	Yu et al⁵	M	80	Abdominal pain, early satiety	Head	14	Right kidney	Trypsin, chymotrypsin	CGA, SYN	Predominately solid and partly acinar	53%	Splenectomy and debulking of the pancreatic mass and continued Sandostatin LAR and chemotherapy	Recurrence and metastasis; still alive at 3 years	Liver and right kidney	2013
3	Yu et al⁵	M	89	Melena	Head	3.9	No	Chymotrypsin	CGA, SYN	Predominately acinar and partly solid	65%	Whipple procedure	Dead (2.5 months) after surgery due to complications	N/A	2013
4	Yu et al⁵	M	60	Abdominal pain	Head	16	No	Trypsin, chymotrypsin	CGA, SYN	Partly acinar and partly solid/trabecular	65%	Subtotal colectomy, partial gastrectomy, and 70% pancreatectomy and chemotherapy	Recurrence and metastasis; dead (6 months)	Liver	2013
5	Yu et al⁵	M	74	Abdominal pain	Body	10	No	Trypsin, chymotrypsin	CGA, SYN	Predominately acinar	10%	Neoadjuvant chemotherapy then underwent distal pancreatectomy and splenectomy and chemotherapy	Metastasis; still alive at 17 months	Wide metastasis	2013
6	Yu et al⁵	M	59	Fatigue, anorexia, jaundice	Head	7.5	No	Trypsin, chymotrypsin	CGA, SYN	Predominately solid	30%–80%	Whipple procedure and adjuvant chemotherapy	Recurrence and 4 months metastasis; still alive at 7 months	Liver	2013
7	Ogbonna et al⁷	F	57	Epigastric pain	Body	2.5	No	Trypsin, chymotrypsin PAS+cytokeratin	CGA, SYN	Predominately solid	40%–45%	Distal pancreatectomy and splenectomy and adjuvant chemotherapy	N/A	N/A	2013
8	Sullivan et al¹⁸	M	75	Liver transplant, multiple masses	Genu	0.6	Liver	Trypsin, chymotrypsin	CGA, SYN	Half acinar component and half solid component	40%	Chemotherapy	N/A	N/A	2013
9	Sullivan et al¹⁸	M	51	Acute pancreatitis	Body	1.6	No	Trypsin, chymotrypsin	CGA, SYN	Predominately solid and partly acinar	7%–11%	Distal pancreatectomy	N/A	N/A	2013
10	Lee et al⁶	M	66	Vague midepigastric discomfort	Head	3.1	Liver	Trypsin, cytokeratin CAM 5.2	CGA, SYN	Half acinar component and half solid component	35%	Chemotherapy	Dead (21 months)	N/A	2013
11	Soubra et al²¹	M	52	Epigastric pain, fatigue and jaundice	Head	1.5	No	Trypsin, chymotrypsin	CGA, SYN	Predominately solid and partly acinar	N/A	PD and chemotherapy	After 12 months recurrence, still alive 30 months	Liver	2011
12	Kobayashi et al¹³	M	75	Asymptomatic	Tail	7	No	Trypsin, PAS+	CGA, SYN	Predominately acinar and partly solid	N/A	Distal pancreatectomy with lymph node dissection	6 months without recurrence	N/A	2010
13	Chung et al²²	F	59	Watery diarrhea	Tail	8	No	Trypsin, PAS+	SYN	Half acinar component and half solid component	N/A	A partial pancreatectomy along with a splenectomy	N/A	N/A	2010
14	Kyriazi et al²	M	74	Asymptomatic	Head	12	No	Trypsin, C56, CK7	CGA, SYN	Predominately acinar and partly solid	80%	A modified Whipple procedure	Dead (21 months)	N/A	2009
15	Imaoka et al¹⁰	M	80	Generalized swollen lymph nodes	Head	4	No	Trypsin, chymotrypsin, lipase	CGA, SYN	Predominately acinar and partly solid	N/A	Systemic chemotherapy and Whipple procedure	N/A	N/A	2008
16	Ohike et al⁴	M:F 2:4	58.4	N/A	N/A	8.2 (n=2)	N/A	N/A	N/A	N/A	N/A	Surgery resection	N/A	N/A	2004
17	Mizuno et al¹²	F	67	Zollinger–Ellison syndrome	Body	N/A	SMV	α-1-antitrypsin	CGA, SYN gastrin insulin	N/A	N/A	Chemotherapy	Dead (8 years)	Wide metastasis	2001
18	Skacel et al²³	M	75	N/A	Tail	5.5	No	Chymotrypsin α-1-antitrypsin	SYN	N/A	N/A	Surgery resection	10 months without recurrence	N/A	2000
19	Skacel et al²³	M	69	N/A	Head	10	No	Chymotrypsin α-1-antitrypsin	SYN	N/A	N/A	Surgery resection	Dead (20 months)	N/A	2000
20	Ogawa et al²⁴	M	50	Asymptomatic regular medical checkup	Head	3	No	PAS+ α-1-antichymotrypsin	CGA	Half acinar component and half solid component	N/A	A pylorus-preserving PD	18 months without recurrence	N/A	2000
21	Frank et al²⁵	M	61	Abdominal pain, diarrhea,	Head and body	4.9	Liver	PAS+ Trypsinogen	NSE, CGA	Half acinar component and half solid component	N/A	PD, left hepatectomy, chemotherapy	Metastasis at 3 months; dead (2 years and 9 months)	Liver	1998
22	Shimoike et al²⁶	M	28	Convulsions	Tail	3	Liver	Trypsinα-1-antichymotrypsin	NSE, CGA	N/A	N/A	Biopsy and TAE, chemotherapy	Dead (10 months)	N/A	1997
23	Cho et al²⁷	F	52	Jaundice	Head	6	SMV	PAS+ amylase	NSE, CGA somatostatin and gastrin	Predominately solid and partly acinar	N/A	PD	Alive (1 year)	N/A	1996
24	Klimstra et al¹¹	M	81	Nausea, abdominal pain	Tail	3	No	Trypsin, chymotrypsin, lipase	CGA gastrin	Predominately acinar and partly solid	N/A	Surgery resection	Alive (3 months)	N/A	1994
25	Klimstra et al¹¹	M	70	Backaches, incidental mass	Multicentric	10	Lung, liver	Trypsin, chymotrypsin	CGA, CEA	Predominately solid and partly acinar	N/A	Surgery resection	Dead (3 months)	N/A	1994
26	Klimstra et al¹¹	F	64	Hematemesis	Head	10	No	Trypsin, lipase	CGA, SYN, somatostatin	Predominately solid and partly acinar	N/A	Biopsy and bypass	Dead (1 year and 6 months)	N/A	1994
27	Klimstra et al¹¹	F	48	Incidental mass	Tail	11	No	Trypsin, chymotrypsin, lipase	CGA, SYN, CEA	Predominately solid and partly acinar	N/A	Surgery resection	Alive with recurrence (12 months)	Liver	1994
28	Klimstra et al¹¹	F	79	Abdominal pain	Head	10	No	Trypsin, chymotrypsin, lipase	CGA, SYN	Predominately solid and partly acinar	N/A	Biopsy and bypass, chemotherapy, radiation	Alive (12 months)	N/A	1994
29	Ichijima et al²⁸	F	6	Abdominal mass	Tail	8	No	PAS+	Tryptophan immunoperoxidase	N/A	N/A	Surgery resection	Alive (13 years)	N/A	1985
30	Ulich et al²⁹	F	30	Epigastric pain	Head	9.3	No	PAS+ lipase	Immunoperoxidase	Half acinar component and half solid component	N/A	PD	Alive (4 months)	N/A	1982

Notes:

Tumor size.

Treatment of anterior.

Treatment of posterior.

Year of publication.

Abbreviations: CEA, carcinoembryonic antigen; CGA, chromogranin A; F, female; M, male; N/A, not available; NSE, neuron-specific enolase; PAS, periodic acid–Schiff; PD, pancreaticoduodenectomy; SMV, superior mesenteric artery; SYN, synaptophysin; TAE, transcatheter arterial embolization.