Figure 1.

Patterns of invasion and expression of MMP-1, PAR-1, and CD105 (magnification ×200).

Notes: (A–D) Hematoxylin and eosin-stained oral squamous cell carcinoma specimens representative of POI types I, II, III, and IV, respectively. (E–H) MMP-1 expression differed by POI type: the higher the grade of invasion, the stronger the expression of MMP-1. (I–L) PAR-1 expression differed by POI types, similar to MMP-1. Strong staining was also clearly observed in the cytoplasm of both tumor and inflammatory cells. (M–P) The expression strength of CD105 differed by POI type.

Abbreviations: HE, hematoxylin-eosin; MMP-1, matrix metalloproteinase-1; PAR-1, protease activated receptor-1; POI, patterns of invasion.