Figure 2.

Kaplan-Meier survival curves for 74 patients with oral squamous cell carcinoma (log-rank test).

Notes: Expression of MMP-1 (A), expression of PAR-1 (B), microvessel density (C), and POI (D). High microvessel density and high expression of MMP-1 and PAR-1 were significantly associated with shorter overall survival (P<0.001). Patients with POI types I and II had longer survival times than those with POI types III and IV.

Abbreviations: MMP-1, matrix metalloproteinase-1; PAR-1, protease activated receptor-1; POI, patterns of invasion.