Table 3.
Relationship between clinicopathological parameters and MMP-1 expression, PAR-1 expression, and MVD in patients with oral squamous cell carcinoma (n=74)
| Variable | MMP-1 P-value |
PAR-1 P-value |
MVD P-value |
|
|---|---|---|---|---|
| Age (years) | <55 versus ≥55 | NS | NS | NS |
| Gender | Male versus female | NS | NS | NS |
| Differentiated | Well versus moderately/poorly | NS | NS | NS |
| Clinical stage | I + II versus III + IV | 0.005 | 0.012 | NS |
| Recurrence | No versus yes | NS | NS | NS |
| POI | I + II versus III + IV | 0.020 | 0.046 | 0.021 |
| Lymph node involvement | No versus yes | 0.023 | 0.010 | NS |
Note: Correlation was considered significant at P<0.05 (bold values).
Abbreviations: MMP-1, matrix metalloproteinase-1; PAR-1, protease-activated receptor-1; MVD, microvessel density; POI, patterns of invasion; NS, not statistically significant.