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. 2015 Jul 3;8:1603–1610. doi: 10.2147/OTT.S73731

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© 2015 Yan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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(A) Cytotoxicity of gefitinib and rmhTRAIL in human NSCLC PC9 cell lines. It is showed the cytotoxic effect in human NSCLC cell lines by gefitinib or rmhTRAIL in a concentration- and time-dependent manner; (B) Interaction between gefitinib and rmhTRAIL in PC9 cells.

Notes: The graph on the left-hand side shows rmhTRAIL (50 ng/mL) with gefitinib at different doses. The graph on the right-hand side shows gefitinib (0.01 μmol/L) with rmhTRAIL at different doses.

Abbreviations: rmhTRAIL, recombinant mutant human tumor necrosis factor-related apoptosis-inducing ligand; NSCLC, non-small cell lung cancer; h, hours; G, gefitinib.