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. 2015 Jul 3;8:1603–1610. doi: 10.2147/OTT.S73731

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© 2015 Yan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Induction of apoptosis and cell cycle change. (A) Apoptosis in following single agent and in combination treatment: 1: Control (PC9 cells); 2: rmhTRAIL; 3: Gefitinib; 4: combination treatment. (B) Cell cycle distribution in following single agent as well as combination treatment: 1: Control (PC9 cells); 2: rmhTRAIL; 3: Gefitinib; 4: combination treatment. (C) Two drug combinations enhance apoptotic cell death with respect to monotherapy. N: Control (PC9 cells); T: rmhTRAIL; G: gefitinib; T + G: combination treatment.

Notes: *Indicates P<0.05; **indicates P<0.01 versus the experimental value.

Abbreviation: rmhTRAIL, recombinant mutant human tumor necrosis factor-related apoptosis-inducing ligand.