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. 2015 Jul 3;8:1603–1610. doi: 10.2147/OTT.S73731

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© 2015 Yan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The expression of various apoptotic proteins (A, B), differentially expressed of apoptotic proteins in human NSCLC PC9 cell lines (C), and DR5 and caspase3 gene expression in PC9 cells in following single agent as well as combination treatment (D).

Notes: The two drug combinations up-regulated DR5, cleaved-caspases 3 and BAX protein expression; and down-regulated FLIP protein expression. A significantly enhanced gene expression is observed in PC9 cells after gefitinib and rmhTRAIL treatment (D).