Table 1.
C1 | G + T
|
|||||
---|---|---|---|---|---|---|
G (μmol/L) | T (ng/mL)
|
|||||
5 | 10 | 25 | 50 | 125 | ||
24 h | 0.01 | 1.08±0.001 | 1.04±0.001 | 1.03±0.002 | 0.98±0.001 | 0.91±0.001 |
48 h | 0.01 | 1.19±0.001 | 1.17±0.001 | 0.82±0.001 | 0.79±0.003 | 0.86±0.001 |
72 h | 0.01 | 1.15±0.005 | 1.00±0.018 | 0.86±0.001 | 0.69±0.003 | 0.59±0.003 |
| ||||||
C1 |
G + T
|
|||||
T (ng/mL) |
G (μmol/L)
|
|||||
0.005 | 0.01 | 0.05 | 0.1 | 0.5 | ||
| ||||||
24 h | 50 | 1.05±0.002 | 0.98±0.001 | 0.92±0.001 | 0.83±0.001 | 0.77±0.001 |
48 h | 50 | 1.17±0.001 | 0.97±0.001 | 0.92±0.003 | 0.93±0.007 | 0.83±0.018 |
72 h | 50 | 1.2±0.005 | 0.94±0.001 | 0.77±0.022 | 0.61±0.001 | 0.67±0.182 |
Notes: G indicates gefitinib; T indicates rmhTRAIL.
Abbreviation: rmhTRAIL, recombinant mutant human tumor necrosis factor-related apoptosis-inducing ligand; h, hours