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. 2015 Jul 3;8:1603–1610. doi: 10.2147/OTT.S73731

Table 1.

Synergistic effects of gefitinib combination with rmhTRAIL in different concentration (C1)

C1 G + T
G (μmol/L) T (ng/mL)
5 10 25 50 125
24 h 0.01 1.08±0.001 1.04±0.001 1.03±0.002 0.98±0.001 0.91±0.001
48 h 0.01 1.19±0.001 1.17±0.001 0.82±0.001 0.79±0.003 0.86±0.001
72 h 0.01 1.15±0.005 1.00±0.018 0.86±0.001 0.69±0.003 0.59±0.003

C1 G + T
T (ng/mL) G (μmol/L)
0.005 0.01 0.05 0.1 0.5

24 h 50 1.05±0.002 0.98±0.001 0.92±0.001 0.83±0.001 0.77±0.001
48 h 50 1.17±0.001 0.97±0.001 0.92±0.003 0.93±0.007 0.83±0.018
72 h 50 1.2±0.005 0.94±0.001 0.77±0.022 0.61±0.001 0.67±0.182

Notes: G indicates gefitinib; T indicates rmhTRAIL.

Abbreviation: rmhTRAIL, recombinant mutant human tumor necrosis factor-related apoptosis-inducing ligand; h, hours