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Ability of leads of the different series of indenoindoles to inhibit drug efflux by ABCB1 or ABCC1.
Notes: Each indenoindole derivative was assayed at either 2 μM (black bars) or 10 μM (white bars) for its ability to alter the efflux of either rhodamine 123 by ABCB1 (A) or calcein by ABCC1 (B) assayed by flow cytometry, as for the efflux of mitoxantrone by ABCG2 in Table 1. The inhibition produced by the two reference inhibitors, 5 μM GF120918 and 35 μM verapamil, was taken as 100%.
