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Time-dependent plasma concentrations of PTX after the intravenous administration of a single dose of reference formulation (Taxol®) (solid circles, 5 mg/kg) or the PTX/DM-β-CD inclusion complex-loaded CS nanoparticles (empty circles, equivalent PTX dose of 5 mg/kg) in rats.
Note: The data are expressed as the mean ± SD (n=3).
Abbreviations: CS, chitosan; DM-β-CD, (2,6-di-O-methyl)-β-cyclodextrin; NP, nanoparticle; PTX, paclitaxel; SD, standard deviation.
