Table 5.

Pharmacokinetic parameters of the PTX/DM-β-CD inclusion complex-loaded CS nanoparticles in rats following a single dose of intravenous administration (5 mg/kg PTX)

Pharmacokinetic parameters	Taxol®	PTX/DM-β-CD inclusion complex-loaded CS nanoparticles
t1/2α (hours)	0.03±0.01	0.04±0.01
t1/2α (hours)	4.56±0.53	6.10±0.98
Kel (h−1)	1.74±0.46	0.54±0.16**
CL (l·h−1·kg−1)	0.04±0.01	0.02±0.01
Vss (l·kg−1)	0.29±0.08	0.15±0.04*
AUC0→24h (µg·h·mL−1)	52.23±5.17	139.59±11.52***
MRT (hours)	6.06±0.87	8.55±0.29*

Notes: Given values are means ± SD (n=3).

^*P<0.05,

^**P<0.01,

^***P<0.001 vs PTX treatment.

Abbreviations: AUC_0→24h, the area under the plasma drug concentration–time curve over the period of 24 hours; CL, clearance; CS, chitosan; DM-β-CD, (2,6-di-O-methyl)-β-cyclodextrin; K_el, elimination rate constant; MRT, mean residence time; PTX, paclitaxel; SD, standard deviation; t_1/2α, half-life of distribution phase; t_1/2α, half-life of elimination phase; V_ss, apparent volume of the plasma compartment.