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. 2015 Jul 10;10(7):e0132604. doi: 10.1371/journal.pone.0132604

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© 2015 Manocha et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 8 — Microglial BV2 cells were pretreated for 1 hour with DMSO vehicle (v) or varying concentrations of LDDN-0003499 then stimulated with (A, B, C) 50nM Aβ 1–42 or (E) 25ng/ml LPS in the maintained presence/absence of LDDN-0003499. Media were collected from the cells following 24h stimulation and used to quantify changes in TNF-α (A, E), IL-6 (B) or IL-1β (C) secretion via ELISA. Secreted values from three independent experiments were averaged ± SD (*p< 0.05 respective control vs Aβ, $p<0.05 vs. Aβ only). (D) Media from treated cells were also used assess cell viability via the LDH release assay. Absorbance values were averaged ±SD.