Table 2. Caco-2 Permeability.

LDDN-0003499 was assessed for human oral availability and blood brain barrier penetration using a Caco-2 permeability assay.

Test Article	Test Conc.	Assay Duration	mean A→B Papp (10-6 cm s-1)	mean B→A Papp (10-6 cm s-1)	Efflux Ratio	Comment
ranitidine	10 μM	2 hr	0.30	3.1	10.3	low permeability control
warfarin	10 μM	2 hr	27.1	10.4	0.38	high permeability control
talinolol	10 μM	2 hr	0.071	9.8	138	P-gp efflux control
LDDN-0003499	10 μM	2 hr	19.0	16.2	0.85	high permeability

Papp: apparent permeability rate coefficient. Efflux Ratio: P_app(B→A) / P_app(A→B).