Table 1.

Characteristics (mean±SEM) of lean or obese pigs with or without hypertension (HT, n=7 each group)

Parameters	Sham		HT		P value for two-way ANOVA
	Lean	Obese	Lean	Obese	Diet	HT	DietXHT
Body weight (kg)	31.4±4.3	45.0±5.7*	35.7±2.1	45.3±1.1*†	0.001	0.30	0.52
MAP (mmHg)	108.0±7.1	113.9±5.8	122.67±4.4*	137.2±5.5*†‡	0.09	0.004	0.004
Heart rate (bpm)	61.3±2.6	67.0±7.0	76.6±5.4*	84.5±6.4*‡	0.54	0.018	0.87
RPP (mmHgxbpm)	83.4±7.5	91.9±10.6	115.7±8.3*	137.7±9.7*†	0.24	0.002	0.017
Total cholesterol (mg/dl)	97.0±2.9	388.0±48.1*	85.4±5.0	346.7±40.6*†	<0.001	0.81	0.58
LDL (mg/dl)	38.3±2.9	243.0±21.9*	32.4±3.0	187.3±27.3*†	<0.001	0.66	0.09
Triglycerides (mg/dl)	26.0±5.6	37.6±13.9	17.4±2.9	34.6±5.6	0.16	0.77	0.10
HOMA-IR (μU/ml×mg/dl)	3.6±0.3	6.7±2.4*	2.6±0.5	10.5±2.9*†	0.005	0.63	0.006
TNF-α (pg/ml)	38.1±15.4	55.0±11.8	138.9±49.7*	101.4±23.4*	0.77	0.029	0.52
sE-selectin (pg/ml)	5.6±3.9	5.7±5.7	15.4±7.1	36.8±10.8*†‡	0.17	0.017	0.005
8-epi-Isoprostane (pg/ml)	126.9±24.4	142.2±27.4	97.9±8.0	139.5±12.8	0.27	0.49	0.73
PRA (ng/ml/hr)	0.02±0.01	0.10±0.03	0.07±0.02	0.16±0.06*	0.005	0.07	0.94
LVMM (g)	39.8±2.6	44.7±3.7	49.0±4.7	52.1±4.3*	0.25	0.034	0.10
E/A	1.6±0.1	1.5±0.2	1.5±0.2	1.1±0.2*‡	0.28	0.021	0.023
Stroke volume (ml)	36.5±3.6	35.6±4.6	34.0±2.5	35.8±2.2	0.74	0.74	0.67
Ejection fraction (%)	59.5±4.2	62.0±3.3	63.8±2.0	62.4±3.7	0.96	0.54	0.60
Cardiac output (mlxbpm)	2.5±0.2	2.4±0.2	2.5±0.3	2.9±0.2‡	0.40	0.15	0.023

MAP: mean arterial pressure; RPP: rate pressure product; LDL: low-density lipoprotein; HOMA-IR: homeostasis model assessment insulin resistance; TNF-α: tumor necrosis factor-α; PRA: plasma renin activity; LVMM: left ventricular muscle mass.

^*p<0.05 vs. Lean-sham,

^†p<0.05 vs. Lean-HT,

^‡p<0.05 vs. Obese-sham.