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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Jan 10;1850(10):2069–2076. doi: 10.1016/j.bbagen.2014.12.025

Figure 5. Pin1 helps coordinate mitosis in cycling cells.

Figure 5

Entry into and progression through the cell cycle requires the cell to release its tight control on the expression of mitotic proteins. Pin1 helps to coordinate the required suppression of the many proteins that suppress growth and mitosis with the expression of mitogens. In this sense, Pin1 acts as a molecular “switch,” allowing the cell to transition from maintenance to reproductive mode.