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. Author manuscript; available in PMC: 2016 Jan 9.
Published in final edited form as: Nature. 2015 Jun 1;523(7559):212–216. doi: 10.1038/nature14465

Extended Data Figure 9. X chromosome inactivation.

Extended Data Figure 9

a, Distributions of promoter CG methylation (mCG) levels (mCG/CG), gene body non-CG methylation (mCH) levels (mCH/CH), gene body mCG levels and promoter mCH levels in genes previously reported to express from only one allele (inactivated) or biallelically (escapee)63. Black ticks show median, and bars indicate 25-75th percentile range. Genes more prone to escaping inactivation have lower promoter mCG, higher gene body mCH, higher gene body mCG and higher promoter mCH in females. b-e, Discriminability analysis using b, gender-specific gene-body mCH, c, promoter mCG, d, promoter mCH and e, gene body mCG to predict the escapee status of X-linked gene, respectively. Among them, gene body mCH is the most predictive feature of chromosome X inactivation escapees.