Table 4.

Gene expression analysis: Normalized fold increase of H-HA/L-HA complex 0.1 and 1 % (w/v), relative to gene expression transforming growth factor beta 1 (TGF-β1) and Type I collagen (COLIA1) at different time of analysis. Data represent the mean ± SD of three independent experiments

	TGF-β1		COLIA1
H-HA/L-HA complex (% w/v)	0.1	1	0.1	1
4h	↓↓	↓	~	=
10 h	↑	↓	↑	↓
16 h	↑	↓	↑	↑↑
24 h	=	=	=	↓

Legend: = as the control, ↑ 1.2–5 fold vs control, ↑↑ 5.2–10 fold vs control, ↑↑↑ >10 fold vs control, ↓ 0.1–0.7, ~ 0.8–0.9 fold vs control, ↓↓ < 0.1 fold vs control