Table 2.
Unadjusted and adjusted OR’s for MDT decision to propose nonstandard treatment
| Characteristic | OR unadjusted | 95 % CI | OR adjusted b | 95 % CI | |
|---|---|---|---|---|---|
| Age | <65 years a | 1.22 | 0.7–1.9 | 1.46 | 0.9–2.4 |
| ≥65 years | |||||
| Gender | Male a | 0.72 | 0.4–1.2 | 0.72 | 0.4–1.3 |
| Female | |||||
| Comorbidity score (ACE-27) | Low (0–1) a | 3.06* | 1.9–4.8 | 3.40* | 2.0–5.7 |
| High (2–3) | |||||
| Tumor stage | Early (I-II) a | 5.74* | 3.0–11.0 | 3.40* | 1.4–8.5 |
| Advanced (III-IV) | |||||
| Tumor site | Oral cavity a | ||||
| Pharynx | 2.75* | 1.6–4.9 | 0.94 | 0.4–2.2 | |
| Larynx | 1.69 | 0.9–3.3 | 0.85 | 0.3–2.1 | |
| Prior malignancy | No a | ||||
| Other prior cancer yet treated | 0.78 | 0.3–1.6 | 0.61 | 0.3–1.5 | |
| Prior head and neck cancer yet treated | 1.60 | 0.8–3.1 | 2.56* | 1.1–5.7 | |
| Marital status | Partner a | 1.83* | 1.2–2.9 | 1.68 | 1.0–2.9 |
| Single | |||||
| Children | Yes a | ||||
| No | 1.23 | 0.7–2.1 | 1.07 | 0.6–2.0 | |
| Unknown | 0.79 | 0.4–1.5 | 1.31 | 0.7–2.7 | |
| No contact | 0.84 | 0.7–1.1 | 0.90 | 0.7–1.1 | |
| Standard treatment according to guidelines | Surgery a | ||||
| Radiotherapy | 1.37 | 0.5–4.1 | 1.31 | 0.4–4.5 | |
| Chemoradiation | 8.29* | 3.2–21.5 | 4.79* | 1.3–17.1 | |
| Surgery + radiotherapy | 2.53 | 0.9–7.0 | 1.13 | 0.3–4.0 | |
| Surgery + chemotherapy | 8.00* | 1.6–39.0 | 4.61 | 0.7–29.5 | |
| Surgery + PORT on indication | 0.86 | 0.2–3.3 | 0.98 | 0.2–4.2 | |
| Year of treatment | 2010 a | ||||
| 2011 | 0.71 | 0.4–1.3 | 0.56 | 0.3–1.1 | |
| 2012 | 1.04 | 0.6–1.7 | 1.11 | 0.6 2.0 |
a = reference value, b = odds ratio calculated using multivariate logistic regression analysis adjusting for age, gender, comorbidity, tumor stage, tumor site, prior malignancy, marital status, having children, standard treatment proposal according to guidelines, year of treatment, * = p value < 0.05