Extended Data Figure 7. Characterization of LSL-IDH2 R172K GEMM.
a. Schematic of LSL-IDH2 R172K GEMM (See Methods for details). Mice harboring the LSL-IDH2 R172K allele were crossed with the Alb-Cre strain to target expression to the liver.
b. IF analysis revealed specific expression of IDH2 R172K in CK19+ biliary cells, whereas hepatocytes were negative.
c. IF analysis showing comparable low levels of proliferation (Ki-67) in LSL-R172K and littermate control livers at 3 months of age. Scale bars = 50µm.