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. Author manuscript; available in PMC: 2015 Jul 11.
Published in final edited form as: Nature. 2014 Jul 2;513(7516):110–114. doi: 10.1038/nature13441

Extended Data Figure 7. Characterization of LSL-IDH2 R172K GEMM.

Extended Data Figure 7

a. Schematic of LSL-IDH2 R172K GEMM (See Methods for details). Mice harboring the LSL-IDH2 R172K allele were crossed with the Alb-Cre strain to target expression to the liver.

b. IF analysis revealed specific expression of IDH2 R172K in CK19+ biliary cells, whereas hepatocytes were negative.

c. IF analysis showing comparable low levels of proliferation (Ki-67) in LSL-R172K and littermate control livers at 3 months of age. Scale bars = 50µm.