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. Author manuscript; available in PMC: 2015 Jul 11.
Published in final edited form as: Nature. 2014 Jul 2;513(7516):110–114. doi: 10.1038/nature13441

Extended Data Figure 10. Stem cell features in IDH mutant murine and human IHCC pathogenesis.

Extended Data Figure 10

a. IDH2 R172K expression using mutant-specific antibodies in livers from LSL-R172K and KrasG12D, R172K compound mice showing specific expression of the R172K transgene in Sox9+ oval cells and IHCC. Scale bars = 50µm.

b. Normalized enrichment plot of a cohort of 127 human IHCC samples genotyped for IDH status, showing that the subset of tumors with IDH1/IDH2 mutations exhibits enrichment of a gene signature40 that identifies IHCCs with hepatic stem cell/progenitor features.