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. Author manuscript; available in PMC: 2015 Aug 19.
Published in final edited form as: Nature. 2015 Feb 19;518(7539):344–349. doi: 10.1038/nature14233

Figure 1. TF dynamics during human ESC differentiation.

Figure 1

a. Schematic of the human ESC differentiation system including timeline and key signaling pathways that are modulated.

b. Normalized RNA expression of selected TFs over the differentiation timeline towards endoderm.

c. RNA-seq data of the selected TFs. Factors are ordered by condition where they are most active: ESCs on top, followed by dMS, dEN, dME, and dEC.