Table 1.

Hereditary syndromes associated with high risk of colorectal cancer and principal involved genes

Syndrome	Mendelian pattern	Gene
Lynch syndrome	Autosomal dominant	hMLH1
Familial adenomatous	Autosomal dominant	APC
Attenuated FAP	Autosomal dominant	APC FAP
MUTYH-associated polyposis	Autosomal recessive	MUTYH
Peutz–Jeghers syndrome	Autosomal dominant	STK11
Juvenile polyposis syndrome	Autosomal dominant	SMAD4