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Effects of RPP15 on knee swelling in MSU crystal-induced gouty arthritis rats. Rats were pretreated with either vehicle, RPP15 (0.4, 0.8, and 1.2 g/kg, p.o.), or positive drug indomethacin (3 mg/kg). Knee joint swellings were evaluated at different time points. Data are means ± SD (n = 9). ++ P < 0.01 versus vehicle-control group (control); ∗∗ P < 0.01 versus vehicle with MSU crystal (model).
