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Effect of RPP15 on MSU crystal-induced inflammatory mediator production in the knee joint lavage fluid. To examine the therapeutic potential of RPP15 on gout, cytokines- TNF-α, IL-1β, and IL-8 were measured 24 h after MSU crystal. Data are means ± SD (n = 6). ++ P < 0.01 versus vehicle-control group (control); ∗∗ P < 0.01 versus vehicle with MSU crystal (model).
