Table 2.
Placebo
|
Cabergoline
|
|||||||
---|---|---|---|---|---|---|---|---|
Before | After 16 w | p-value | 95% CI | Before | After 16 w | p-value | 95% CI | |
Sex (M/F) | 4/10 | 4/7 | 7/6 | 7/5 | ||||
Prolactin (ng/mL) | 9.65 ± 0.87 | 9.78 ± 1.01 | 0.92 | -2.91 — 2.65 | 10.23 ± 1.86 | 0.29 ± 0.08 | 0.00 | 6.09 — 13.85 |
BMI (Kg/m2) | 27.50 ± 1.21 | 26.83 ± 1.20 | 0.70 | -2.98 — 4.35 | 30.67 ± 1.54 | 29.77 ± 1.42 | 0.67 | -3.46 — 5.26 |
A1c (%) | 5.70 ± 0.08 | 5.77 ± 0.10 | 0.64 | -0.34 — 0.21 | 5.7 ± 0.13 | 5.59 ± 0.01 | 0.46 | -0.20 — 0.43 |
Weight (Kg) | 73.90 ± 4.35 | 72.18 ± 4.56 | 0.78 | -11.43 — 14.89 | 81.41 ± 4.51 | 79.00 ± 4.16 | 0.69 | -10.31 — 15.41 |
WC* (cm) | 95.72 ± 3.5 | 92.36 ± 3.89 | 0.52 | -7.56 — 14.29 | 104.75 ± 3.29 | 102.33 ± 3.44 | 0.61 | -7.47 — 12.31 |
2h Insulin (µU/L) | 66.22 ± 9.35 | 51.14 ± 10.48 | 0.30 | N.NL. | 77.32 ± 3.75 | 55.23 ± 7.79 | 0.02 | 2.84 — 4.34 |
HOMA2 %B | 96.26 ± 17.36 | 80.90 ± 9.53 | 0.46 | -27.30 — 58.02 | 85.63 ± 5.44 | 98.65 ± 6.06 | 0.12 | -29.93 — 3.88 |
HOMA2 %S | 101.16 ± 19.98 | 109.65 ± 22.91 | 0.78 | -71.91 — 54.93 | 76.76 ± 7.24 | 98.65 ± 6.06 | 0.03 | -41.40 — -2.28 |
HOMA2 IR | 1.54 ± 0.33 | 1.40 ± 0.27 | 0.74 | -0.76 — 1.05 | 1.46 ± 0.14 | 1.14 ± 0.04 | 0.04 | 0.00 — 0.64 |
Value represented as mean ± SEM
Bolded P values are statistically different before and after 16 weeks of treatment
Analysis done based on within group average changed over 16 weeks
Waist Circumferences (WC)