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. Author manuscript; available in PMC: 2015 Jul 12.
Published in final edited form as: Exp Dermatol. 2014 Jul 31;23(9):645–651. doi: 10.1111/exd.12480

Figure 1.

Figure 1

Topical hesperidin prevents the GC-induced abnormalities in SC pH and permeability homoeostasis in murine skin: Both flanks of mice were treated topically with 60 µl of 0.05% clobetasol in propylene glycol/ethanol/water (6/2/2) twice-daily for 9 days. One hour after each clobetasol application, either 70% ethanol alone or 2% hesperidin in 70% ethanol was applied to clobetasol-treated area. On day 10, 18 h after last 70% ethanol or hesperidin application, basal stratum corneum biophysical properties were assessed as described in Materials and Methods. (a) displays stratum corneum capacitance; (b) shows basal transepidermal water loss; (c) indicates the barrier recovery rates; and (d) exhibits skin surface pH. Numbers and significances are indicated in the figures.