Table 1.
Patient No. | Age | Sex | Score on Autism Diagnostic Interview-Revised | Intellectual Disability† | ||
---|---|---|---|---|---|---|
yr | Social | Communication | Restrictive and Repetitive | |||
12 | 2 | M | 14 | 9 (NV) | 6 | No |
13 | 4 | F | 26 | 13 (NV) | 3 | Yes |
14 | 5 | M | NA | NA | NA | Yes |
15 | 5 | F | 24 | 20 (V) | 7 | Yes |
16 | 7 | M | 22 | 18 (V) | 8 | Yes |
17 | 8 | M | 19 | 14 (NV) | 4 | No |
18 | 8 | M | NA | NA | NA | Yes |
19 | 8 | M | 24 | 10 (NV) | 10 | Yes |
20 | 9 | M | 24 | 20 (V) | 6 | No |
21 | 14 | M | 22 | 14 (NV) | 8 | Yes |
22 | 15 | F | 22 | 21 (V) | 5 | No |
To meet the diagnostic classification of autism, the patient must have met cutoff scores in each of three areas of the Autism Diagnostic Interview–Revised (Western Psychological Services): the Qualitative Abnormalities in Reciprocal Social Interaction section (with a cutoff score of 10), the Qualitative Abnormalities in Communication portion (with a cutoff score of 7), and the Restricted, Repetitive, and Stereotyped Patterns of Behavior section (with a cutoff score of 3). All patients met or exceeded cutoffs for a diagnostic classification of autism on the basis of this instrument, except for Patients 14 and 18, for whom no scores were available (NA). The diagnosis of autism in these patients was verified by brain banks and confirmed by a review of records by a research psychologist independent of the brain banks. Additional diagnostic details regarding the patients with autism (listed here) and the controls (Patients 1 to 11) are provided in Table S2 in the Supplementary Appendix. NV denotes nonverbal, and V verbal.
Intellectual disability status was determined on the basis of available standardized IQ scores for Patients 12 through 16 and of a review of available patient records without a standardized IQ measure for Patients 17 through 22.