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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Endocr Relat Cancer. 2015 May 15;22(4):519–530. doi: 10.1530/ERC-15-0134

Table 2.

19 SNVs that lost statistical power after the correction.

Gene SNV Location / Distance to Splice SIFT / PPH2 Population Alelic p-value / OR (CI)
PDE1C rs115957738 p.Asp122 = > 10 bps * EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p=0.184 OR - 0.18 (95% CI. 0.02-1.46)
PDE1C rs116449276 Intron > 10 bps * EUR p=0.001 OR - 1.06 (95% CI. 0.97-1.16)
* ALL p=0.008 OR - 0.05 (95% CI. 0.01-0.27)
PDE1C rs76290787 p.Ser175 = > 10 bps * EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p=0.264 OR - 0.28 (95% CI. 0.03-2.20)
PDE1C rs78021925 Intron > 10 bps * EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p=0.452 OR - 1.72 (95% CI. 0.23-12.9)
PDE2A rs392818 utr-3 > 10 bps * EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p=0.483 OR - 0.63 (95% CI. 0.08-4.77)
PDE2A rs11824084 utr-3 > 10 bps * EUR p=0.001 OR - 1.06 (95% CI. 0.97-1.16)
* ALL p=0.098 OR - 0.24 (95% CI. 0.05-1.06)
PDE2A rs4944557 p.Asp572 = 9 bps * EUR p=0.001 OR - 1.06 (95% CI. 0.97-1.16)
* ALL p=0.381 OR - 0.63 (95% CI. 0.14-2.70)
PDE4B rs34492439 p.Val388 = > 10 bps * EUR p=0.003 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p= **
PDE4B rs114408173 Intron > 10 bps * EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p=0.172 OR - 0.17 (95% CI. 0.02-1.35)
PDE4B rs7534999 c.604-3 C>T 3 bps * EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p=0.587 OR - 0.86 (95% CI. 0.11-6.41)
PDE5A rs3733526 p.Ala93Val > 10 bps Tolerated EUR p=0.052 OR - 0.51 (95% CI. 0.26-0.99)
Benign ALL p=0.080 OR - 0.55 (95% CI. 0.29-1.04)
PDE5A rs114886951 p.Ile778Thr 2 bps Tolerated EUR p=0.034 OR - 16.1 (95% CI. 1.44-179.0)
Damaging ALL p=0.005 OR - 46.4 (95% CI. 4.17-516.0)
PDE6A rs113309832 Intron > 10 bps * EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p=0.295 OR - 0.32 (95% CI. 0.04-2.52)
PDE6B rs61734864 p.Val835 = 2 bps * EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p=0.231 OR - 4.11 (95% CI. 0.53-31.8)
PDE6B rs73058408 c.1722+5 G>A 5 bps * EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p=0.014 OR - 1.03 (95% CI. 0.96-1.09)
PDE6C rs193276411 Intron > 10 bps * EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p=0.148 OR - 0.14 (95% CI. 0.01-1.14)
PDE6C rs76999928 p.Asp157Glu 10 bps Tolerated EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
Damaging ALL p=0.295 OR - 3.03 (95% CI. 0.39-23.1)
PDE8A rs148254104 p.Leu350 = > 10 bps * EUR p=0.011 OR - 0.00 (95% CI. 0.00-0.08)
* ALL p= **
PDE8B rs182775622 p.Ala375 = > 10 bps * EUR p=0.040 OR - 1.03 (95% CI. 0.96-1.09)
* ALL p=0.028 OR - 0.01 (95% CI. 0.00-0.23)
*

Unmeasurable

**

Absent data; EUR: European population; ALL: All 1092 individuals from 1000 Genome Project; OR: odds ratio; CI: confidence interval.