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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Alzheimers Dement. 2015 Jan 12;11(10):1202–1211. doi: 10.1016/j.jalz.2014.11.003

Table 3.

Mean Differences in WMH volumes and FA in statin exposed vs statin non-exposed groups in the lowest tertile of 3MS score (score range: 59 to 92, mean score: 86).

Neuroimaging
measures compared
between exposed vs.
unexposed		 Unadjusted
comparison
Estimate ±
Standard Error
(p value)
 Adjusted
comparisonsa
Estimate ±
Standard Error
(p value)
 Adjusted
comparisons b
Estimate ±
Standard Error
(p value)
White Matter Hyperintensities
Total white matter −2.32 × 10−3 ± 0.81 × 10−3 (0.005) −2.44 × 10−3 ± 0.8 × 10−3 (0.003) −3.22 × 10−3 ± 0.9 × 10−3 (0.0009)
Anterior thalamic tract −5.05 × 10−3 ± 0.262 × 10−3 (0.043) −0.53 × 10−3 ± 0.27 × 10−3 (0.053) −0.75 × 10−3 ± 0.30 × 10−3 (0.016)
Superior longitudinal fasciculus −0.334 × 10−3 ± 0.17 × 10−3 (0.035) −0.30 × 10−3 ± 0.17 × 10−3 (0.081) −0.38 × 10−3 ± 0.19 × 10−3 (0.049)
Corpus callosum- genu −0.304 × 10−3 ± 0.133 × 10−3 (0.002) −0.32 × 10−3 ± 0.13 × 10−3 (0.018) −0.34 × 10−3 ± 0.16 × 10−3 (0.035)
Corpus callosum-splenium −0.487 × 10−3 ± 0.166 × 10−3 (0.016) −0.49 × 10−3 ± 0.17 × 10−3 (0.005) −0.57 × 10−3 ± 0.19 × 10−3 (0.0048)
Fractional Anisotropy values:
Total white matter 8.35 × 10−3 ± 2.74 × 10 3 (0.004) 7.94 × 10−3 ± 2.76 × 10 3 (0.005) 7.23 × 10−3 ± 3.27 × 10 3 (0.030)
Anterior thalamic tract 2.29 × 10−2 ± 0.817 × 10−2 (0.005) 2.11 × 10−2 ± 0.84 × 102 (0.014) 1.15 × 10−2 ± 0.87 × 102 (0.19)
Superior longitudinal fasciculus 1.73 × 10−2 ± 0.781 × 10−2 (0.033) 1.83 × 10−2 ± 0.78 × 10−2 (0.021) 1.45 × 10−2 ± 0.98 × 10−2 (0.14)
Corpus callosum- genu 0.80 × 10−2 ± 0.26 × 10−2 (0.002) 0.79 × 10−2 ± 0.27 × 10−2 (0.005) 0.89 × 10−2 ± 0.32 × 10−2 (0.007)
Corpus callosum-splenium 0.14 × 10−2 ± 0.54 × 10−2 (0.009) 1.38 × 10−2 ± 0.56 × 10−2 (0.015) 1.04 × 10−2 ± 0.66 × 10−2 (0.122)
a

adjusted for demographics (age, race, gender, education), health behaviors (smoking, alcohol use) and cardiovascular risk (angina, myocardial infarction, coronary artery bypass, angioplasty, diabetes mellitus, peripheral arterial disease, stroke).

b

adjusted for covariates in ‘a’ and, apolipoprotein epsilon-4 (ApoE4) and serum low-density lipoprotein levels (LDL).