Table 2.
Analgesic drugs consumed within 24 hours before testing procedures (N=25)
| Fiber Function (number of subjects) [Mechanism] | Drug Class | Drug Name (subject code number)1 | Dose mg/24 hrs1 |
|---|---|---|---|
| Normal & abnormal mechanical and thermal (n=8) [mixed sensitization] | Non-opioid | Acetaminophen (12/6, 24) | 1300/0 |
| NSAID | Acetylsalicylic acid (1) | 325 | |
| Naproxen (13/16) | 500/0 | ||
| Ibuprophen (24, 2, 14) | 0 | ||
| Step 2 opioid | Tramadol (16/14) | 50/200 | |
| Hydrocodone (2/13/24) | 0/10/0 | ||
| Step 3 opioid | Morphine – Injectable (13) | 45 | |
| Morphine-immediate release (9) | 15 | ||
| Morphine-sustained release (9) | 30 | ||
| Methadone (14) | 40 | ||
| Hydromorphone (14) | 0 | ||
| Adjuvant | Amitriptyline (14) | 75 | |
| carbamazepine (14) | 200 | ||
| Normal mechanical; Abnormal thermal (n=1) [peripheral sensitization] | Step 3 opioid | Hydromorphone –injectable (22) | 0 |
| Abnormal mechanical and thermal (n=15) [central sensitization] | Non-opioid | Acetaminophen (5, 10, 17, 25/23/19) | 0/650/1,500 |
| Ibuprophen (4/17, 23/25) | 3200/0/800 | ||
| Acetylsalicylic acid (8) | 650 | ||
| Step 2 opioid | Hydrocodone (4/11/21) | 25/UK/0 | |
| Codeine (23) | 0 | ||
| Tylenol with codeine or hydrocodone (5, 6, 7, 8, 17, 21, 23) | 0 | ||
| Tramadol (10/25) | 200/0 | ||
| Tylenol with codeine (19) | 90 | ||
| Step 3 opioid | Morphine-immediate release (5) | 0 | |
| Fentanyl patch (10) | 375 | ||
| Morphine -immediate release (23) | 0 | ||
| Morphine -injectable (23) | 0 | ||
| Morphine -sustained release (8, 18, 23) | 0 | ||
| Oxycodone -controlled release (3) | 10 | ||
| Adjuvant | Amitriptyline (20) | 5 | |
| All normal (n=1) [No sensitization] | Non-opioid | Acetaminophen (15) | 650 |
| NSAID | Ibuprophen (15) | 800 | |
| Step 3 opioid | Morphine-immediate release (15) | 0 |
Key:
1
/ separates code numbers corresponding to doses in the last column