Table 2.

Distribution of HemR polymorphisms among OM and commensal NTHi isolates.

Polymorphism			OM		Commensal
1° aaa	Position	2° aab	N1°/Ntotalc	%	N1°/Ntotalc	%	PR (95% CI)	p-value	OR (95% CI)	p-value	Perm. p-valued
L	4	I/F 11/5	80/85	94.1%	50/61	82.0%	1.15 (1.01 - 1.31)	0.02	3.52 (1.15 - 10.73)	0.03	0.02
R	8	H	63/85	74.1%	53/61	86.9%	0.85 (0.73 - 1.00)	0.06	0.43 (0.18 - 1.05)	0.06	0.04
L	15	F	77/85	90.6%	43/61	70.5%	1.29 (1.08 - 1.53)	<0.01	4.03 (1.62 - 10.04)	<0.01	<0.01
V	16	I	80/85	94.1%	51/61	83.6%	1.13 (1.00 - 1.27)	0.04	3.14 (1.01 - 9.71)	0.05	0.03
A	70	V	67/85	78.8%	59/61	96.7%	0.82 (0.72 - 0.92)	<0.01	0.13 (0.03 - 0.57)	0.01	<0.01
R	131	K	81/85	95.3%	51/61	83.6%	1.14 (1.01 - 1.29)	0.02	3.97 (1.18 - 13.33)	0.03	0.02
K	157	R	80/85	94.1%	51/61	83.6%	1.13 (1.00 - 1.27)	0.04	3.14 (1.01 - 9.71)	0.05	0.03
Q	164	K	82/85	96.5%	54/61	88.5%	1.09 (0.99 - 1.20)	0.06	3.54 (0.88 - 14.30)	0.08	0.06
N	303	H/R 13/4	79/85	92.9%	50/61	82.0%	1.13 (0.99 - 1.29)	0.04	2.90 (1.01 - 8.33)	0.05	0.03
T	324	I/E 8/4	81/85	95.3%	53/61	86.9%	1.10 (0.98 - 1.22)	0.07	3.06 (0.88 - 10.66)	0.08	0.07
Y	405	F	83/85	97.6%	54/61	88.5%	1.10 (1.00 - 1.21)	0.02	5.38 (1.08 - 26.87)	0.04	0.02
D	578	N	50/85	94.1%	52/61	85.2%	1.10 (0.98 - 1.24)	0.07	2.77 (0.88 - 8.73)	0.08	0.07
P	589	I	53/85	62.4%	27/61	44.3%	1.41 (1.02 - 1.95)	0.03	2.09 (1.07 - 4.07)	0.03	0.02
I*	659*	V*
N*	663*	Y*	67/85	78.8%	36/61	59.0%	1.34 (1.05 - 1.69)	0.01	2.58 (1.25 - 5.36)	0.01	0.01
F*	664*	L*
A*	666*	V*
I	718	V	60/85	70.6%	32/61	52.5%	1.35 (1.02 - 1.77)	0.03	2.18 (1.10 - 4.32)	0.03	0.02

^aConsensus amino acid at that position.

^bAlternative amino acid at that position. Polymorphisms at positions 4, 303, and 324 have multiple alternative amino acids.

^cPrevalence of the consensus (or 1°) amino acid at a given position within OM or commensal isolates.

^dP-values calculated by a permutation test.

^*The I659V, N663Y, F664L, and A666V polymorphisms always co-occur, and are thus treated as a single entity in the statistical analyses.