Table 1.

Toxicity and outcomes of salvage brachytherapy for prostate cancer recurrence after external beam irradiation

Study, year	Salvage therapy	n	Median follow-up (months)	Grade 3/4 toxicity	Outcome
Łyczek et al. [10]	HDR 30 Gy/3 fx/3 impl	115	No information	12.2% GU 0.9% GI	46% bPFS in patients with PSA < 6 18% bPFS in patients with PSA > 6
Scala et al. [11]	HDR 36 Gy/6 fx/2 impl	10	18.5	70% grade 2 or greater	70% dfs
Jo et al. [12]	HDR 22 Gy/2 fx/1 impl	11	29	0%	63% bNED
Morikawa et al. [13]	HDR 32 Gy/4 fx/1 impl	29	22	0%	79% bDFS
Chen et al. [14]	HDR 36 Gy/6 fx/2 impl	52	59.6	2%	51% 5y bDFS
Lahmer et al. [15]	PDR 60 Gy/2 impl	18	21	0-17%	57% PSA-rfsp
Kukiełka et al. [16]	HDR + IHT 30 Gy/3 fx/3 impl	25	13	0%	74% 2y bDFS

PSA-rfsp – PSA-recurrence free survival probability, bDFS – biochemical disease-free survival, bPFS – biochemical progression-free survival, bNED – biochemical no evidence of disease, HDR – high-dose-rate brachytherapy, PDR – pulsed-dose-rate brachytherapy, IHT – interstitial hyperthermia; impl – implantation