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. 2015 Jun 29;2015:354517. doi: 10.1155/2015/354517

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Copyright © 2015 Dmitry A. Chistiakov et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Biogenesis of human miR-221/222. miRNA-encoding genes are shown in red boxes. In the common promoter, TATA boxes are marked by green triangles. Poly(A) signals are displayed with blue arrows. Numbers designate the distance between the regulatory transcription elements (in bp) and the length of each miRNA gene and intergenic spacer. The sequence of a mature miRNA duplex is presented in red color. Ago2: Argonaute-2; DGCR8: DiGeorge syndrome critical region gene 8; GW182: glycine-tryptophan protein of 182 kDa; MTDH: metadherin; PACT: protein kinase R-activating protein; Ran-GTP: GTP-binding nuclear protein Ran; SND1: staphylococcal nuclease domain-containing protein 1; TRBP: TAR RNA-binding protein.