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. 2015 Feb 25;24(13):1521–1535. doi: 10.1089/scd.2014.0588

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Copyright 2015, Mary Ann Liebert, Inc.

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FIG. 3. — (A) The mRNA expression of selected genes by qRT-PCR. The mRNA levels of 13 genes that were significantly upregulated in SFCs compared with primary cancer cells were evaluated. Eleven genes were significantly overexpressed in OSCs compared with control fallopian tubes (*P<0.05). (B) The relative mRNA levels in chemoresistant cancers compared with chemosensitive cancers (*P<0.05). LEF1, PYY, NKX3-2, and WNT3A were significantly upregulated in chemoresistant cancers compared with chemosensitive cancers. (C) Associations between clinicopathologic parameters and mRNA expression levels by qRT-PCR. (a) PYY upregulation (>2-fold increase vs. the normal control group) was significantly associated with nodal metastasis (*P<0.05). (b) VAV3 upregulation (>2-fold increase vs. the normal control group) was associated with distant metastasis (*P<0.05). (c) The upregulation of PYY (>2-fold), FOXA2 (>6-fold), and NKX3-2 (>10-fold) each correlated with chemoresistance in OSC (*P<0.05, respectively).