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. 2015 Mar 11;24(14):1658–1671. doi: 10.1089/scd.2014.0496

FIG. 7.

FIG. 7.

Increased density of blood vessels in lungs injected with S1P-primed MSC. (A) Immunohistochemical detection of rat RECA-1-positive vessels in lung tissues (magnification,×100). The normal and muscularized/occluded vessels were marked as arrow and asterisk, respectively. The boxed area in left panel image is shown in the right panel at higher magnification (×200, scale bar=200 μm). Nuclei were stained with 4′,6-diamidino-2-phenylindole (blue). (B) The number of RECA-1+ normal or muscularized (asterisk) vessels was assessed from at least 11 randomly selected fields and presented as mean±SEM. **P<0.01 compared to MCT only (normal vessel), ##P<0.01 compared to MCT only (transformed vessel), $P<0.05 compared to MSC+MCT (normal vessel) (two-way ANOVA with Bonferroni post-test). MSC, hCB-MSC; S1P-MSC, hCB-MSC primed with 0.2 μM S1P for 3 h before injection.