Table 2. Results from top genetic variants associated with post-operative pulmonary complications.

			Discovery Population				Replication Population		Pooled Population
Gene	SNP	bModel	OR (unadjusted)	P-value	aOR	P-value	aOR	P-value	aOR	P-value
TRAF2	rs6560652	dom	4.10 (1.97–8.51)	0.00015	4.65 (2.03–10.68)	0.00029	1.34 (0.71–2.53)	0.37	2.25 (1.38–3.66)	0.0011
MAP2K4	rs12452497	add	0.64 (0.41–1.00)	0.050	0.57 (0.35–0.92	0.023	0.63 (0.41–0.98)	0.039	0.60 (0.43–0.83)	0.0018
MAP3K5	rs9389421	dom	1.70 (0.98–2.94)	0.058	2.00 (1.08–3.72)	0.028	1.76 (0.97–3.19)	0.063	1.92 (1.25–2.93)	0.0027
MAP3K5	rs13195420	dom	0.60 (0.35–1.00)	0.051	0.52 (0.29–0.91)	0.023	0.58 (0.33–1.01)	0.055	0.55 (0.37–0.81)	0.0029
MAP3K5	rs13193586	dom	1.73 (0.82–3.65)	0.15	2.49 (1.08–5.75)	0.033	2.04 (0.78–5.30)	0.14	2.24 (1.20–4.18)	0.011
MAP3K5	rs13203080	rec	3.90 (1.14–13.34)	0.030	4.86 (1.14–20.74)	0.033	n/a	n/a	5.38 (1.33–21.72)	0.018
TNF	rs1800629	dom	2.10 (1.18–3.44)	0.011	2.46 (1.35–4.46)	0.0032	1.00 (0.55–1.82)	0.99	1.55 (1.02–2.34)	0.039
DAXX	rs3130100	dom	1.34 (0.77–2.35)	0.31	1.90 (1.01–3.57)	0.047	1.11 (0.61–2.02)	0.74	1.42 (0.93–2.18)	0.11
MAP2K4	rs7207011	dom	2.93 (1.01–8.50)	0.048	3.63 (1.11–11.82)	0.032	0.95 (0.35–2.54)	0.91	1.70 (0.82–3.50)	0.15
TNFRSF1B	rs17037696	dom	1.67 (1.00–2.79)	0.052	1.76 (1.01–3.08)	0.048	0.77 (0.44–1.32)	0.34	1.12 (0.76–1.65)	0.56
TRAF2	rs7019752	dom	2.06 (1.11–3.80)	0.021	2.17 (1.09–4.33)	0.028	0.55 (0.28–1.07)	0.076	1.04 (0.66–1.65)	0.86

^aAdjusted for age at surgery, gender, intra-operative transfusion, % DLCO predicted, and chest wall resection.

^bModel of inheritance: dom – dominant, rec – recessive, add – additive.

Bold indicates significance (P < 0.05) and underline indicates borderline significance (P < 0.10) in replication or pooled population.