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. 2015 May 29;6(7):809–813. doi: 10.1021/acsmedchemlett.5b00169

Figure 4.

Figure 4

Static and cidal curve with different concentrations of compound 27. (A) Compound 27 (1× and 10× MIC concentration) were incubated with S. aureus for 24 h, and at regular time points, aliquot was taken and CFU was calculated. In vivo antimicrobial activity of the compound 27. (B) BALB/C mice were initially made neutropenic by injecting cyclophosphamide (150 mg/kg of body weight), followed by S. aureus ATCC 29213 injection. After 3 h of post infection, compound 27 and vancomycin at 15 mg/kg of body weight was injected into mice twice at an interval of 3 h between injection. After 24 h, the mice were sacrificed and the organs (spleen, kidney, liver) were crushed before plating them on the TH plates for CFU determination. The data from three independent experiments were pooled, and the P-value was determined using the ANOVA on ranks by using Sigma stat software (***P < 0.001 and **P < 0.05).