Table 1. Antibacterial Activity of Chalcone–Thiazole Hybridsa.
| minimum inhibitory conc (MIC) in μM |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| bacteria |
fungi |
||||||||||||
| compound | 1 | 2 | 3 | 3a | 3b | 3c | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| 22 | >104.9 | >104.9 | 6.5 | 13.1 | 6.5 | 3.3 | >104.9 | >104.9 | >104.9 | >104.9 | >104.9 | >104.9 | >104.9 |
| 23 | >101.5 | >101.5 | 12.7 | 12.7 | 12.7 | 3.2 | >101.5 | >101.5 | >101.5 | >101.5 | >101.5 | >101.5 | >101.5 |
| 24 | >110.5 | >110.5 | 13.8 | 13.8 | 13.8 | 13.8 | >110.5 | >110.5 | >110.5 | >110.5 | >110.5 | >110.5 | >110.5 |
| 25 | >106.7 | >106.7 | 13.3 | 13.3 | 6.7 | 3.3 | >106.7 | >106.7 | >106.7 | >106.7 | >106.7 | >106.7 | >106.7 |
| 26 | >97.9 | >97.9 | 12.2 | 12.2 | 12.2 | 12.2 | >97.9 | >97.9 | >97.9 | >97.9 | >97.9 | >97.9 | >97.9 |
| 27 | >92.5 | >92.5 | 5.8 | 11.6 | 5.8 | 1.4 | >92.5 | >92.5 | >92.5 | >92.5 | >92.5 | >92.5 | >92.5 |
| 28 | >89.8 | >89.8 | 11.2 | 11.2 | 11.2 | 5.6 | >89.8 | >89.8 | >89.8 | >89.8 | >89.8 | >89.8 | >89.8 |
| 29 | >93.9 | >93.9 | 23.5 | 11.7 | 11.7 | 11.7 | >93.9 | >93.9 | >93.9 | >93.9 | >93.9 | >93.9 | >93.9 |
| 30 | >94.9 | >94.9 | 11.9 | 11.9 | 11.9 | 3.0 | >94.9 | >94.9 | >94.9 | >94.9 | >94.9 | >94.9 | >94.9 |
| 31 | >108.1 | >108.1 | 27.0 | 13.5 | 13.5 | 13.5 | >108.1 | >108.1 | >108.1 | >108.1 | >108.1 | >108.1 | >108.1 |
| 32 | >104.5 | >104.5 | 26.1 | 26.1 | 26.1 | 26.1 | >104.5 | >104.5 | >104.5 | >104.5 | >104.5 | >104.5 | >104.5 |
| 33 | >102.4 | >102.4 | 51.2 | 51.2 | 51.2 | 51.2 | >102.4 | >102.4 | >102.4 | >102.4 | >102.4 | >102.4 | >102.4 |
| 34 | >110.0 | >110.0 | 27.5 | 27.5 | 27.5 | 13.7 | >110.0 | >110.0 | >110.0 | >110.0 | >110.0 | >110.0 | >110.0 |
| Gen | 6.5 | 1.6 | 1.6 | 104.9 | 3.3 | 104.9 | 3.3 | >104.9 | 104.9 | 104.9 | 104.9 | 104.9 | 104.9 |
| Nor | 0.0 | 1.0 | 0.5 | 33.6 | 1.0 | 0.5 | 0.1 | >33.6 | 33.6 | 33.6 | 33.6 | 33.6 | 33.6 |
| Van | >156.6 | >156.6 | 2.4 | 9.8 | 1.2 | 2.4 | >156.6 | >156.6 | 156.6 | 156.6 | 156.6 | 156.6 | 156.6 |
| Flu | >34.5 | >34.5 | >34.5 | >34.5 | >34.5 | >34.5 | >34.5 | 0.7 | 1.4 | 1.4 | 22.1 | 22.1 | 1.4 |
| AmB | >54.1 | >54.1 | >54.1 | >54.1 | >54.1 | >54.1 | >54.1 | 0.0 | 0.1 | 0.3 | 0.3 | 0.5 | 0.0 |
a
1. E. coli (ATCC 9637); 2. P. aeruginosa (ATCC BAA-427); 3. S. aureus (ATCC 25923); 3a. S. aureus (ATCC 700699 Methicillin Resistant); 3b. S. aureus (ATCC 29213); 3c. S. aureus (ATCC 33592 Methicillin and Gentamicin Resistant); 4. K. pneumoniae (ATCC 27736); 5. C. albicans; 6. C. neoformans; 7. S. schenckii; 8. T. mentagrophytes; 9. A. fumigates; 10. C. parapsilosis (ATCC 22019); Gen, Gentamicin; Nor, Norfloxacin; Van, Vancomycin; Flu, Fluconazole; AmB, Amphotericin-B.