Figure 1.

Mean molecular weight and cLogP values of oral drugs according to time of publication (from ref (100), updated with drugs launched up to 2014), and patented targets and optimized compounds from 18 companies during 2000–10 (from ref (4)). Post-1990 oral drugs show increased physical properties versus earlier drugs and are further examined in Table 2. cLogP is the calculated 1-octanol–water partition coefficient (from Biobyte (http://www.biobyte.com/bb/prod/clogp40.html).