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. 2015 May 20;6(7):804–808. doi: 10.1021/acsmedchemlett.5b00150

Scheme 2. Synthesis of a 1-Deaza-(N)-methanocarba-2-triazolyladenosine Analogue 29.

Scheme 2

Ar = 5-chlorothiophen-2-yl. Reagents: (i) NaN3, sodium ascorbate, CuSO4.5H2O, l-proline, Na2CO3, tBuOH-H2O, 100 °C, microwave, 1.5 h, 92%; (ii) Ar–C≡CH, sodium ascorbate, CuSO4·5H2O, TBTA, tBuOH-H2O, rt, 89%; (iii) 10%TFA-MeOH, 70 °C, 78%.