. 2015 May 19;6(7):736–740. doi: 10.1021/acsmedchemlett.5b00117

Table 1. Human NK₃R In Vitro Bioactivity, LogD_7.4, Ligand Efficiency Metrics,¹⁰⁻¹² and Off-Target Safety SAR.

graphic file with name ml-2015-00117d_0005.jpg

N = 3, %RSD ≤ 5.

CYP 3A4, 2D6, 2C9, 2C19, and 1A2, respectively (N = 2, <10% variability).

N = 3, coefficient of variation < 6%.

Table 1. Human NK3R In Vitro Bioactivity, LogD7.4, Ligand Efficiency Metrics,10−12 and Off-Target Safety SAR.